Description

Human Dental Pulp Stem Cells ( hDPSCs )

hDPSCs Product Description

Human Dental Pulp Stem Cells ( hDPSCs ) are mesenchymal stem cells derived from extracted teeth, including third molars or orthodontically indicated teeth. DPSCs possess exceptional regenerative potential, making them a preferred choice over bone marrow or adipose-derived stem cells for dental and periodontal research.

These cells offer minimally invasive harvesting, high proliferative capacity, strong osteogenic differentiation, resistance to inflammation-induced senescence, and low immunogenicity. hDPSCs actively modulate the immune microenvironment, influencing T cells, B cells, macrophages, dendritic cells, and neutrophils, which supports restoration of periodontal tissue balance and regeneration.

hDPSCs express canonical mesenchymal markers CD73, CD90, CD105, Nestin, CD44, CD109, Nanog, Sox2, SSEA4, and CD166, while lacking hematopoietic and immune lineage markers such as CD19, CD34, CD45, CD11b, and HLA-DR. Osteogenic gene expression is robust, including ALP, RUNX2, BMP2, OPN, and OSX, demonstrating their potential for bone and dental tissue engineering.

The Celprogen hDPSCs product is available in multiple formats for research flexibility:

• Frozen Vials shipped with dry ice (Cat#36086-01)

• T25, T75, T150, T225 Plated Cells shipped at room temperature

hDPSCs can be cultured for up to 120 population doublings (≈12 passages) and require Celprogen-specific media and extracellular matrix (Cat# M36086-01 & E36086-01) for guaranteed viability and optimal performance.

These cells have been extensively utilized in biocompatibility and cytotoxicity studies, including:

• Testing lactose-modified chitosan-based gels for dental scaffolding

• Evaluating cytotoxic effects of orally dissolving probiotic tablets on oral cells

• Comparing restorative dental materials’ cytotoxicity, with alkasite materials showing higher cytotoxicity

hDPSCs are ideal for dental material research, regenerative dentistry, tissue engineering, and in vitro modeling of oral diseases. For non-academic applications, please consult Celprogen for pricing and product access.

Key Features of hDPSCs :

• Human-derived dental pulp stem cells ( hDPSCs )

• Plastic-adherent, colony-forming mesenchymal cells

• Osteogenic and immunomodulatory potential

• Multiple culture formats: Frozen vials and plated cells

• Guaranteed when used with Celprogen media and ECM

• Ideal for cytotoxicity, biocompatibility, and regenerative studies

Publications Related to hDPSCs :

1- Human Dental pulp stem cells (hDPSCs): isolation, enrichment and comparative differentiation of two sub-populations.

2- Effect of Motiflor AS probiotic for oral health on cell viability in human gingival fibroblasts and human dental pulp stem cells

3- In Vitro Examination of The Cytotoxicity of Alkasite Restorative Material on Dental Pulp Stem Cells

4- Biomimetic, Multiresponsive, and Self-Healing Lactose-Modified Chitosan (CTL)-Based Gels Formed via Competitor-Assisted Mechanism

Articles:

Treating Periodontal Disease with Dental Stem Cell Injection

DPSCs Product Datasheet: Click Here

DPSCs Safety Datasheet: Click Here

 

 

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